A liver-specific inverse agonist of LXR
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SR9238

Item No. 18771

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylic acid, ethyl ester
CAS Number
1416153-62-2
Molecular Formula
C31H33NO7S2
Formula Weight
595.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 5 mg/ml
λmax
257 nm
SMILES
CS(C1=CC=CC(C2=CC=C(CN(CC3=CC=C(C(OCC)=O)O3)S(C4=C(C)C=C(C)C=C4C)(=O)=O)C=C2)=C1)(=O)=O
InChi Code
InChI=1S/C31H33NO7S2/c1-6-38-31(33)29-15-14-27(39-29)20-32(41(36,37)30-22(3)16-21(2)17-23(30)4)19-24-10-12-25(13-11-24)26-8-7-9-28(18-26)40(5,34)35/h7-18H,6,19-20H2,1-5H3
InChi Key
HDZWHJYZJWLTAG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    10 mg

    $194

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SR9238 is an inverse agonist of the two LXR isoforms, LXRα and LXRβ (IC50s = 214 and 43 nM, respectively).1 It displays liver specificity in vivo, with little action at peripheral LXR. SR9238 suppresses hepatic lipogenesis, inflammation, lipid accumulation, and fibrosis in mouse models of non-alcoholic steatohepatitis.1,2 It also reduces plasma cholesterol levels in diet-induced obese mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffett, K., Solt, L.A., El-Dien, B., et al. A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem. Biol. 8(3), 559-567 (2013).

    2. Griffett, K., Welch, R.D., Flaveny, C.A., et al. The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. Mol. Metab. 4(4), 353-357 (2015).