An inhibitor of the CBP and p300 bromodomains
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PF-CBP1

Item No. 18811

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(3,5-dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-benzimidazole
CAS Number
1962928-21-7
Molecular Formula
C29H36N4O3
Formula Weight
488.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
223, 285 nm
SMILES
CCCOC(C=C1)=CC=C1CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5
InChi Code
InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6,8-11,20H,4,7,12-19H2,1-3H3
InChi Key
CGWBJJZOKGZCSJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    PF-CBP1 is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively).1 It displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins.1 PF-CBP1 reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages.1 It also suppresses the expression of RGS4 (regulator of G protein signaling 4) in primary cortical neurons.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Piatnitski Chekler, E.L., Pellegrino, J.A., Lanz, T.A., et al. Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem. Biol. 22(12), 1588-1596 (2015).