An anticonvulsant
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Methsuximide

Item No. 19058

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dimethyl-3-phenyl-2,5-pyrrolidinedione
CAS Number
77-41-8
Synonyms
  • (±)-Mesuximide
  • N,2-dimethyl-2-Phenylsuccinimide
  • PM 396
Molecular Formula
C12H13NO2
Formula Weight
203.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:40): 0.02 mg/mlEthanol: 25 mg/ml
SMILES
CN(C(CC1(C)C2=CC=CC=C2)=O)C1=O
InChi Code
InChI=1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3
InChi Key
AJXPJJZHWIXJCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $43

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    25 mg

    $102

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    50 mg

    $169

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    100 mg

    $274

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    Product Description

    Methsuximide is an anticonvulsant.1 It is a substrate for the cytochrome P450 (CYP) isoform CYP2C19 and inhibits the metabolism of chlorproguanil and proguanil (Item No. 30675) when used at a concentration of 100 µM.2 Methsuximide (100 mg/kg) protects against leptazol-induced convulsions in rats.1 Formulations containing methsuximide have been used in the treatment of petit mal seizures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nicholls, P.J., and Orton, T.C. The physiological disposition of 14C-methsuximide in the rat. Br. J. Pharmacol. 45(1), 48-59 (1972).

    2. Wright, J.D., Helsby, N.A., and Ward, S.A. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br. J. Clin. Pharmacol. 39(4), 441-444 (1995).