An SGLT inhibitor
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Sotagliflozin

Item No. 19141

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
methyl 5S-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-β-L-xylopyranoside
CAS Number
1018899-04-1
Synonyms
  • LP 802034
  • ​LX4211
Molecular Formula
C21H25ClO5S
Formula Weight
424.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
224, 275 nm
SMILES
ClC(C=CC([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](SC)O1)=C2)=C2CC3=CC=C(OCC)C=C3
InChi Code
InChI=1S/C21H25ClO5S/c1-3-26-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(27-20)28-2/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21-/m1/s1
InChi Key
QKDRXGFQVGOQKS-CRSSMBPESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $631

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Sotagliflozin is an inhibitor of sodium-glucose cotransporters (SGLTs; IC50s = 36 and 1.8 nM for human SGLT1 and SGLT2, respectively).1 It increases plasma glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) levels, as well as glucose levels in the small intestine, cecum, and colon, in mice when administered at a dose of 60 mg/kg.2 Sotagliflozin (2 and 30 mg/kg) decreases blood glucose levels in a mouse model of diabetes induced by cyclophosphamide (Item No. 13849).3 Formulations containing sotagliflozin have been used in the treatment of type 1 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zambrowicz, B., Freiman, J., Brown, P.M., et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin. Pharmacol. Ther. 92(2), 158-169 (2012).

    2. Powell, D.R., Smith, M., Greer, J., et al. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose. J. Pharmacol. Exp. Ther. 345(2), 250-259 (2013).

    3. Powell, D.R., Doree, D., Jeter-Jones, S., et al. Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes. Diabetes Metab. Syndr. Obes. 8, 121-127 (2015).