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SCH 772984

Item № 19166
CAS № 942183-80-4
Purity ≥95%
product image
                (CAS 942183-80-4)
     1 mg $29.00 0.00
     5 mg $131.00 0.00
     10 mg $232.00 0.00

Pricing updated 2019-05-23. Prices are subject to change without notice.


The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens.1 SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively).2 It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 µM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS.2 It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.3

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Technical Information
Formal Name
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
233, 323 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Seger, R., and Krebs, E.G. The MAPK signaling cascade The FASEB Journal 9, 726-735 (1995).

2. Morris, E.J., Jha, S., Restaino, C.R., et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors Cancer Discov. 3(7), 742-750 (2013).

3. Cahikaud, A., Tacconi, E., Zimmer, J., et al. A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics Nature Chemical Biology 10(10), 853-860 (2014).

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