A negative control for JJH260, an AIG1 inhibitor
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ABC34

Item No. 19385

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-methoxyphenyl)-1-piperazinecarboxylic acid, hexahydro-1,3-dioxo-7-[(4-phenoxyphenyl)methyl]imidazo[1,5-a]pyrazin-2-yl ester
CAS Number
1831135-56-8
Molecular Formula
C31H33N5O6
Formula Weight
571.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMF:PBS (pH 7.2)(1:3): 0.25 mg/mLDMSO: 10 mg/mL
λmax
235 nm
SMILES
O=C1N(OC(N2CCN(C3=CC=C(OC)C=C3)CC2)=O)C(N4CCN(CC5=CC=C(OC6=CC=CC=C6)C=C5)CC41)=O
InChi Code
InChI=1S/C31H33N5O6/c1-40-25-13-9-24(10-14-25)33-16-18-34(19-17-33)31(39)42-36-29(37)28-22-32(15-20-35(28)30(36)38)21-23-7-11-27(12-8-23)41-26-5-3-2-4-6-26/h2-14,28H,15-22H2,1H3
InChi Key
JJXNIRULKJQOCI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $107

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    Product Description

    ABC34 is an inactive control probe for JJH260 (Item No. 19384), the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs).1 ABC34 demonstrates an IC50 value greater than 25 µM for the inhibition of 9-PAHSA (Item No. 17037) but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat. Chem. Biol. 12(5), 367-372 (2016).