β-Zearalenol

β-Zearalenol is a mycotoxin, an agonist of estrogen receptor α (ERα), and an active metabolite of zearalenone (Item No. 11353).^1,2 β-Zearalenol increases the proliferation of MCF-7 cells that endogenously express ERα (EC₅₀ = 8.49 nM).² It is also an androgen receptor antagonist (IC₅₀ = 23.10 µM for the human receptor). β-Zearalenol (100 µM) decreases path and straight line velocity and cell linearity, as well as increases curvilinear velocity and the levels of acrosome-reacted sperm, in isolated stallion sperm.³ α-Zearalenol induces cytotoxicity in isolated phorbol 12-myristate 13-acetate-stimulated pig neutrophils (IC₅₀ = 56.8 µM). It increases intracellular superoxide levels when used at a concentration of 1 µM, and decreases IL-8 supernatant levels in in the same cells at 10 µM.⁴ β-Zearalenol (50 mg/kg) increases uterine weight in immature female mice.¹

WARNING This product is not for human or veterinary use.

1. Ueno, Y., and Tashiro, F. α-Zearalenol, a major hepatic metabolite in rats of zearalenone, an estrogenic mycotoxin of Fusarium species. J. Biochem. 89(2), 563-571 (1981).

2. Molina-Molina, J.M., Real, M., Jimenez-Diaz, I., et al. Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays. Food Chem. Toxicol. 74, 233-239 (2014).

3. Filannino, A., Stout, T.A.E., Gadella, B.M., et al. Dose-response effects of estrogenic mycotoxins (zearalenone, alpha- and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm. Reprod. Biol. Endocrinol. 9, 134 (2011).

4. Marin, D.E., Taranu, I., Burlacu, R., et al. Effects of zearalenone and its derivatives on the innate immune response of swine. Toxicon 56(6), 956-953 (2010).