Eupatilin

Eupatilin is a flavonoid that has been found in Artemisia and has diverse biological activities.^1,2,3,4,5 It inhibits cell growth in A375 melanoma cells when used at concentrations ranging from 25 to 800 µM.¹ Eupatilin binds to peroxisome proliferator-activated receptor α (PPARα; IC₅₀ = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARα, but not PPARγ, when used at concentrations ranging from 10 to 300 µM.² It prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells.⁶ Eupatilin also inhibits 5-lipoxygenase (5-LO) activity in cultured mastocytoma cells (IC₅₀ = 14 µM).³ In vivo, eupatilin (5, 10, and 15 mg/kg) reduces pulmonary edema and levels of the lung injury markers surfactant protein A (SPA) and SPD in a rat model of LPS-induced acute lung injury.⁴ It reduces serum levels of histamine and increases survival in a mouse model of allergic anaphylactic shock induced by compound 48/80 (Item No. 22173).⁵

WARNING This product is not for human or veterinary use.

1. Shawi, A.A., Rasul, A., Khan, M., et al. Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G₂/M phase cell cycle arrest in human melanoma A375 cells. Afr. J. Pharm. Pharmacol. 5(5), 582-588 (2011).

2. Choi, Y., Jung, Y., and Kim, S.N. Identification of eupatilin from Artemisia argyi as a selective PPARα agonist using affinity selection ultrafiltration LC-MS. Molecules 20(8), 13753-13763 (2015).

3. Koshihara, Y., Neichi, T., Murota, S.i., et al. Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai. FEBS Lett. 158(1), 41-44 (1983).

4. Liu, H., Hao, J., Wu, C., et al. Eupatilin alleviates lipopolysaccharide-induced acute lung injury by inhibiting inflammation and oxidative stress. Med. Sci Monit. 25, 8289-8296 (2019).

5. Song, E.-H., Chung, K.-S., Kang, Y.-M., et al. Eupatilin suppresses the allergic inflammatory response in vitro and in vivo. Phytomedicine 42, 1-8 (2018).

6. Choi, E.J., Oh, H.M., Na, B.R., et al. Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress. Pharmacol. Res. 25(6), 1355-1364 (2008).