An anti-inflammatory flavone
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Sinensetin

Item No. 19751

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
CAS Number
2306-27-6
Synonyms
  • Pedalitin Permethyl ether
Molecular Formula
C20H20O7
Formula Weight
372.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/ml
λmax
215, 241, 327 nm
SMILES
O=C1C2=C(OC)C(OC)=C(OC)C=C2OC(C3=CC=C(OC)C(OC)=C3)=C1
InChi Code
InChI=1S/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(27-14)10-17(24-3)19(25-4)20(18)26-5/h6-10H,1-5H3
InChi Key
LKMNXYDUQXAUCZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $185

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    25 mg

    $315

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    Cayman Chemical
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    Product Description

    Sinensetin is a polymethoxylated flavone that is present in the Southeast Asian medical plant O. stamineus, as well as in orange oil. It has been shown to enhance adipogenesis and lipolysis by increasing cAMP levels in 3T3-L1 cells.1 Sinensetin is also reported to inhibit α-glucosidase and α-amylase activity in vitro, indicating its potential usefulness in the control of glucose absorption.2 Additionally, sinensetin has been shown to suppress the expression of genes associated with inflammation by regulating IκBα protein levels in LPS-activated macrophages.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, S.-I., Shin, H.-S., and Kim, S.-J. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Bio. Pharm. Bull. 38(4), 552-558 (2015).

    2. Mohamed, E.A., Ahmad, M., Ang, L.F., et al. Evaluation of α-glucosidase inhibitory effect of 50% ethanolic standardized extract of Orthosiphon stamineus benth in normal and streptozotocin-induced diabetic rats. Evid-Based Compl. Alt. 2015:754931, (2015).

    3. Shin, H.-S., Kang, S.-I., Yoon, S.-A., et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci. Biotechnol. Biochem. 76(4), 847-849 (2012).