An inhibitor of tubulin polymerization
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BNC-105

Item No. 36930

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-methanone
CAS Number
945771-74-4
Molecular Formula
C20H20O7
Formula Weight
372.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: insolPBS (pH 7.2): insol
SMILES
O=C(C1=C(C)OC2=C1C=CC(OC)=C2O)C3=CC(OC)=C(C(OC)=C3)OC
InChi Code
InChI=1S/C20H20O7/c1-10-16(12-6-7-13(23-2)18(22)19(12)27-10)17(21)11-8-14(24-3)20(26-5)15(9-11)25-4/h6-9,22H,1-5H3
InChi Key
RADMJHVVIZTENA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $124

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    10 mg

    $220

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    25 mg

    $429

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    50 mg

    $674

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    Cayman Chemical
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    Product Description

    BNC-105 is an inhibitor of tubulin polymerization.1 It inhibits bovine tubulin polymerization in a cell-free assay (EC50 = 3 µM). BNC-105 inhibits the proliferation of human umbilical vein endothelial cells (HUVECs) and human abdominal aorta endothelial cells (HAAECs; EC50s = 0.31 and 0.1 nM, respectively). It inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 2.4 nM), as well as a panel of 9 additional cancer cell lines (IC50s = 0.16-18.4 nM).2 BNC-105 (1 nM) inhibits HUVEC capillary tube formation in a Matrigel™ assay.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kremmidiotis, G., Leske, A.F., Lavranos, T.C., et al. BNC105: A novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol. Cancer Ther. 9(6), 1562-1573 (2010).

    2. Flynn, B.L., Gill, G.S., Grobelny, D.W., et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J. Med. Chem. 54(17), 6014-6027 (2011).