A neprilysin inhibitor
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Pro-drug Form(s)
36260AHU377 21473AHU377 (calcium salt)
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LBQ657

Item No. 19829

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
γS-[(3-carboxy-1-oxopropyl)amino]-αR-methyl-[1,1'-biphenyl]-4-pentanoic acid
CAS Number
149709-44-4
Synonyms
  • Sacubitrilat
Molecular Formula
C22H25NO5
Formula Weight
383.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 30 mg/mLEthanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
λmax
254 nm
SMILES
O=C(CCC(O)=O)N[C@@H](C[C@@H](C)C(O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1
InChi Code
InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
InChi Key
DOBNVUFHFMVMDB-BEFAXECRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $145

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    10 mg

    $270

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    Product Description

    LBQ657 is an inhibitor of neprilysin (IC50 = 5 nM).1 It is selective for neprilysin over angiotensin converting enzyme (ACE) when used at a concentration of 10 μM. LBQ657 inhibits neprilysin cleavage of enkephalin, glutaryl-Ala-Ala-Phe-β-napthylamide, and atrial natriuretic factor (IC50s = 5, 0.74, and 5.3 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ksander, G.M., Ghai, R.D., deJesus, R., et al. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J. Med. Chem. 38(10), 1689-1700 (1995).