A prodrug form of LBQ657
Related Products
Active Metabolite(s)
19829LBQ657
Alternative(s)
36260AHU377
Labeled Version(s)
25264AHU377-d4
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AHU377 (calcium salt)

Item No. 21473

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1’-biphenyl]-4-pentanoic acid, 4-ethyl ester, hemicalcium salt
CAS Number
1369773-39-6
Synonyms
  • Sacubitril
Molecular Formula
C24H28NO5 • 1/2Ca
Formula Weight
430.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 5 mg/ml
λmax
254 nm
SMILES
C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.[Ca+2]
InChi Code
InChI=1S/2C24H29NO5.Ca/c2*1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h2*4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;;+2/p-2/t2*17-,21+;/m11./s1
InChi Key
DDLCKLBRBPYKQS-OXXXZDCLSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $75

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    25 mg

    $158

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    50 mg

    $241

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    100 mg

    $333

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    Product Description

    AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Item No. 19829).1 It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used for the treatment of mild to moderate hypertension and chronic heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ksander, G.M., Ghai, R.D., deJesus, R., et al. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J. Med. Chem. 38(10), 1689-1700 (1995).