A prodrug form of LBQ657
Related Products
Active Metabolite(s)
19829LBQ657
Alternative(s)
21473AHU377 (calcium salt)
Labeled Version(s)
25264AHU377-d4
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AHU377

Item No. 36260

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1′-biphenyl]-4-pentanoic acid, α-ethyl ester
CAS Number
149709-62-6
Synonyms
  • Sacubitril
Molecular Formula
C24H29NO5
Formula Weight
411.5
Purity
≥98%
Formulation
A 100 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 100 mg/ml
λmax
252 nm
SMILES
C[C@@H](C(OCC)=O)C[C@H](NC(CCC(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1
InChi Code
InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
InChi Key
PYNXFZCZUAOOQC-UTKZUKDTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $72

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    250 mg

    $143

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    1 g

    $358

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    Product Description

    AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Item No. 19829).1 It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ksander, G.M., Ghai, R.D., deJesus, R., et al. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J. Med. Chem. 38(10), 1689-1700 (1995).