An inhibitor of HAT p300
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HAT Inhibitor II

Item No. 19835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-cyclohexanone
CAS Number
932749-62-7
Synonyms
  • Histone Acetyltransferase Inhibitor II
Molecular Formula
C20H16Br2O3
Formula Weight
464.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/ml
λmax
249, 366 nm
SMILES
BrC1=C(O)C=CC(/C=C2CCC/C(C\2=O)=C\C3=CC(Br)=C(O)C=C3)=C1
InChi Code
InChI=1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+
InChi Key
YOLKEKNTCBWPSD-VOMDNODZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $235

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    Product Description

    HAT Inhibitor II is a cell-permeable, selective inhibitor of the histone acetyltransferase p300 (IC50 = 5 µM).1 It does not inhibit PCAF or GCN5 acetyltransferases.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Costi, R., DiSanto, R., Artico, M., et al. Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase. J. Med. Chem 50(8), 1973-1977 (2007).