Isoimperatorin

Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity.^1,2 Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B₁ (Item No. 11293) to reactive metabolites.^2,3 Isoimperatorin also induces the expression of glutathione S-transferase α by activating Nrf2.³

WARNING This product is not for human or veterinary use.

1. Cai, Y., Bennett, D., Nair, R.V., et al. Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkylase by naturally occurring coumarins. Chem. Res. Toxicol. 6(6), 872-879 (1993).

2. Cai, Y., Baer-Dubowska, W., Ashwood-Smith, M., et al. Inhibitory effects of naturally occurring coumarins on the metabolic activation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured mouse keratinocytes. Carcinogenesis 18(1), 215-222 (1997).

3. Pokaharel, Y.R., Han, E.H., Kim, J.Y., et al. Potent protective effect of isoimperatorin against aflatoxin B₁-inducible cytotoxicity in H4IIE cells: Bifunctional effects on glutathione S-transferase and CYP1A. Carcinogenesis 27(12), 2483-2490 (2006).