Imperatorin

Imperatorin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities.^1,2,3,4,5 It scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals (EC₅₀s = 19.48 and 10.93 μM, respectively).¹ Imperatorin (10 nM) reduces NETosis induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in DMSO-differentiated HL-60 neutrophil-like cells.² It decreases the cytopathic effect induced by herpes simplex virus 1 (HSV-1) in Vero cells when used at concentrations of 15.62 and 31.25 µg/ml.³ Imperatorin decreases myeloid cell leukemia-1 (Mcl-1) protein levels and increases mitochondrial membrane depolarization and apoptosis in doxorubicin-resistant HepG2 (R-HepG2) cells, an effect that can be reversed by overexpression of Mcl-1.⁴ It inhibits LPS-induced increases in p38 MAPK, JNK, and IκBα phosphorylation, TNF-α, IL-6, and IL-1β protein levels, and nuclear localization of NF-κB p65 in RAW 264.7 macrophages.⁵ Imperatorin (50 mg/kg) reduces tumor growth in an R-HepG2 liver cancer mouse xenograft model.⁴

WARNING This product is not for human or veterinary use.

1. Bai, Y., Li, D., Zhou, T., et al. Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities. J. Funct. Foods 20, 453-462 (2016).

2. Juanlu, C., Chen, L., Sung, C.-J., et al. Phytochemicals as potential inhibitors of NETosis: Implications for immunothrombosis and chronic disease management. BMC Complement Med. Ther. (2026).

3. Rajtar, B., Skalicka-Woźniak, K., Świątek, Ł., et al. Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B₃ infections. Food Chem. Toxicol. 109(Pt 2), 1026-1031 (2017).

4. Li, X., Zeng, X., Sun, J., et al. Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma. Cancer Lett. 348(1-2), 146-155 (2014).

5. Guo, W., Sun, J., Jiang, L., et al. Imperatorin attenuates LPS-induced inflammation by suppressing NF-κB and MAPKs activation in RAW 264.7 macrophages. Inflammation 35(6), 1764-1772 (2012).