A natural anthraquinone
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Isomer(s)
34757Obtusifolin 40904Questin
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Physcion

Item No. 19863

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione
CAS Number
521-61-9
Synonyms
  • 6-O-methyl Emodin
  • NSC 251670
Molecular Formula
C16H12O5
Formula Weight
284.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
223, 266, 286, 434 nm
SMILES
CC1=CC2=C(C(O)=C1)C(C3=C(O)C=C(OC)C=C3C2=O)=O
InChi Code
InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
InChi Key
FFWOKTFYGVYKIR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $135

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    50 mg

    $236

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    Cayman Chemical
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    Product Description

    Physcion is a natural anthraquinone. It has been reported to have laxative and anti-inflammatory actions, inhibit kinases and tyrosinase, and have cytotoxicity against cancer cells.1 Physcion inhibits 6-phosphogluconate dehydrogenase (IC50 = 38.5 µM), decreasing lipogenesis and RNA biosynthesis in cancer cells, leading to reduced cell proliferation and tumor growth in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chien, S.-C., Wu, Y.-C., and Chen, Z.-W. Naturally occurring anthraquinones: Chemistry and therapeutic potential in autoimmune diabetes. Evid. Based Complement. Altnernat. Med. 2015:35757, (2015).

    2. Lin, R., Elf, S., Shan, C., et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat. Cell Biol. 17(11), 1484-1496 (2015).