An anthraquinone with diverse biological activities
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Obtusifolin

Item No. 34757

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,8-dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione
CAS Number
477-85-0
Molecular Formula
C16H12O5
Formula Weight
284.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
227, 276, 402 nm
SMILES
O=C1C2=C(C(C3=C1C=C(C)C(O)=C3OC)=O)C(O)=CC=C2
InChi Code
InChI=1S/C16H12O5/c1-7-6-9-12(16(21-2)13(7)18)15(20)11-8(14(9)19)4-3-5-10(11)17/h3-6,17-18H,1-2H3
InChi Key
NYRXUBDGDSRBGB-UHFFFAOYSA-N
Origin
Plant/Senna sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $66

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    5 mg

    $285

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    10 mg

    $503

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    25 mg

    $1,099

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    Cayman Chemical
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    Product Description

    Obtusifolin is an anthraquinone that has been found in S. obtusifolia and has diverse biological activities.1,2,3 It prevents IL-1β-induced increases in NF-κB phosphorylation in chondrocytes when used at concentrations ranging from 25 to 200 µM.1 Oral administration of obtusifolin (100 mg/kg) reduces cartilage degradation in a mouse model of osteoarthritis induced by destabilization of the medial meniscus (DMM). Obtusifolin (30 and 90 mg/kg) reduces blood glucose levels, as well as serum malondialdehyde (MDA), nitric oxide (NO), triglyceride, and cholesterol levels, and increases serum superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) activity in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).2 It also reduces inflammatory pain in mice and neuropathic pain in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nam, J.H., Seol, D.-W., Lee, C.-G., et al. Obtusifolin, an anthraquinone extracted from Senna obtusifolia (L.) H.S.Irwin & Barneby, reduces inflammation in a mouse osteoarthritis model. Pharmaceuticals (Basel) 14(3), 249 (2021).

    2. Tang, Y., and Zhong, Z. Obtusifolin treatment improves hyperlipidemia and hyperglycemia: Possible mechanism involving oxidative stress. Cell Biochem. Biophys. 70(3), 1751-1757 (2014).

    3. He, Z.-W., Wei, W., Li, S.-P., et al. Anti-allodynic effects of obtusifolin and gluco-obtusifolin against inflammatory and neuropathic pain. Biol. Pharm. Bull. 37(10), 1606-1616 (2014).