Questin

Questin is an anthraquinone that has been found in A. fumigatus and has diverse biological activities.^1,2,3,4 It inhibits cell division cycle 25B (Cdc25B) phosphatase (IC₅₀ = 34 µg/ml) and reduces the proliferation of SW620 colon cancer cells (GI₅₀ = 0.9 µg/ml).¹ Questin (50 or 100 µM) reduces the viability of A549 lung cancer cells.² It reduces viral replication in MDCK cells infected with influenza A H1N1 or H3N2 (IC₅₀s = 1.92 and 9.62 µM, respectively).³ Questin decreases proliferation of the protozoa T. fetus (MIC = 12.5 µg/ml).⁴

WARNING This product is not for human or veterinary use.

1. Choi, S.-G., and Kim, J. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. Nat. Prod. Res. 21(6), 487-493 (2007).

2. Gauthier, T., Wang, X., Dos Santos, J.S., et al. Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. PLoS One 7(2), e29906 (2012).

3. Liu, N., Peng, S., Yang, J., et al. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301. Fitoterapia 135, 27-32 (2019).

4. Chaudhary, N.K., Pitt, J.I., Lacey, E., et al. Banksialactones and banksiamarins: Isochromanones and isocoumarins from an Australian fungus, Aspergillus banksianus. J. Nat. Prod. 81(7), 1517-1526 (2018).