A PAF receptor antagonist
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Ginkgolide C

Item No. 19872

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
CAS Number
15291-76-6
Synonyms
  • BN 52022
  • 1,7-dihydroxy Ginkgolide A
Molecular Formula
C20H24O11
Formula Weight
440.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 14 mg/ml
SMILES
O=C(O1)[C@@H](C)[C@@]2(O)[C@]1([H])[C@H](O)C34[C@@]25O[C@@]6([H])C3([C@@H](O)C(O6)=O)[C@H](C(C)(C)C)[C@@H](O)[C@H]4OC5=O
InChi Code
InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6-,7+,8+,9+,10-,11+,15+,17?,18?,19-,20-/m1/s1
InChi Key
AMOGMTLMADGEOQ-AEXCBEIUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).1 Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Braquet, P., Esanu, A., Buisine, E., et al. Recent progress in ginkgolide research. Med. Res. Rev. 11(3), 295-355 (1991).

    2. Liou, C.-J., Lai, X.-Y., Chen, Y.-L., et al. Ginkgolide C suppresses adipogenesis in 3T3-L1 adipocytes via the AMPK signaling pathway. Evid. Based Complement. Alternat. Med. 298635 (2015).