A metabolite of propranolol
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

5-hydroxy Propranolol

Item No. 19880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol
CAS Number
81907-82-6
Molecular Formula
C16H21NO3
Formula Weight
275.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
226, 297, 314, 328 nm
SMILES
OC(CNC(C)C)COC1=CC=CC2=C1C=CC=C2O
InChi Code
InChI=1S/C16H21NO3/c1-11(2)17-9-12(18)10-20-16-8-4-5-13-14(16)6-3-7-15(13)19/h3-8,11-12,17-19H,9-10H2,1-2H3
InChi Key
WMYPGILKDMWISO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $103

    Add

    1 mg

    $161

    Add

    5 mg

    $753

    Add

    10 mg

    $1,303

    Add
    Product Description

    5-hydroxy Propranolol is a metabolite of propranolol (Item No. 17291), a β-adrenergic receptor antagonist.1 Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mehvar, R., and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001).

    2. Ellis, S.W., Hayhurst, G.P., Lightfoot, T., et al. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6. Biochem J. 345(Pt 3), 565-571 (2000).

    3. Masubuchi, Y., Hosokawa, S., Horie, T., et al. Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab. Dispos. 22(6), 909-915 (1994).

    4. Ring, J.A., Ghabrial, H., Ching, M.S., et al. Fetal hepatic propranolol metabolism. Studies in the isolated perfused fetal sheep liver. Drug Metab. Dispos. 23(2), 190-196 (1995).

    Product Citations

    Negoro, R., Tasaka, M., Deguchi, S., et al. Generation of HepG2 cells with high expression of multiple drug-metabolizing enzymes for drug discovery research using a PITCh system. Cells 11(10), 1677 (2022).