A potent, selective inhibitor of mTOR
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CC-223

Item No. 19917

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)-pyrazino[2,3-b]pyrazin-2(1H)-one
CAS Number
1228013-30-6
Molecular Formula
C21H27N5O3
Formula Weight
397.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMF:PBS(pH 7.2)(1:1): 0.5 mg/mLDMSO: 25 mg/mLEthanol: 20 mg/mL
λmax
219, 236, 313, 355 nm
SMILES
CO[C@@H]1CC[C@@H](N2C(CN=C3C2=NC(C4=CN=C(C(O)(C)C)C=C4)=CN3)=O)CC1
InChi Code
InChI=1S/C21H27N5O3/c1-21(2,28)17-9-4-13(10-22-17)16-11-23-19-20(25-16)26(18(27)12-24-19)14-5-7-15(29-3)8-6-14/h4,9-11,14-15,28H,5-8,12H2,1-3H3,(H,23,24)/t14-,15-
InChi Key
UFKLYTOEMRFKAD-SHTZXODSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

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    10 mg

    $341

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    25 mg

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    Product Description

    CC-223 is a potent inhibitor of mTOR (IC50 = 16 nM) that shows selectivity for mTOR over a panel of 246 other kinases.1 It blocks signaling through both mTORC1 and mTORC2, inhibiting the phosphorylation of S6RP, 4EBP1, and Akt(S473) in cellular systems.1 CC-223 inhibits growth and induces apoptosis in hematologic and solid tumor cell lines in vitro, and it exhibits dose-dependent tumor growth inhibition in multiple solid tumor xenografts in vivo.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mortensen, D.S., Fultz, K.E., Xu, S., et al. CC-223, a potent and selective inhibitor of mTOR kinase: In vitro and in vivo characterization. Mol. Cancer Ther. 14(6), 1295-1305 (2015).