A selective ERK inhibitor
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TCS ERK 11e

Item No. 19932

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
CAS Number
896720-20-0
Synonyms
  • TCS Extracellular Signal-Related Kinase 11e
  • VX-11e
Molecular Formula
C24H20Cl2FN5O2
Formula Weight
500.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMSO: 25 mg/mLDMSO:PBS (pH 7.2) (1:6): 0.1 mg/mLEthanol: 1 mg/mL
λmax
266, 329 nm
SMILES
FC1=CC=C(NC2=NC=C(C)C(C3=CNC(C(N[C@H](CO)C4=CC(Cl)=CC=C4)=O)=C3)=N2)C(Cl)=C1
InChi Code
InChI=1S/C24H20Cl2FN5O2/c1-13-10-29-24(31-19-6-5-17(27)9-18(19)26)32-22(13)15-8-20(28-11-15)23(34)30-21(12-33)14-3-2-4-16(25)7-14/h2-11,21,28,33H,12H2,1H3,(H,30,34)(H,29,31,32)/t21-/m1/s1
InChi Key
WUTVMXLIGHTZJC-OAQYLSRUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    25 mg

    $437

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    Product Description

    TCS ERK 11e is an orally bioavailable inhibitor of extracellular signal-related kinase 2 (ERK2; Ki <2 nM).1 It is over 200-fold selective against related kinases GSK3, Aurora Kinase A, and Cdk2 with Ki values of 395, 540, and 852 nM, respectively.1 TCS ERK 11e has been shown to block the proliferation of HT29 cells with an IC50 value of 48 nM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aronov, A.M., Tang, Q., Martinez-Botella, G., et al. Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J. Med. Chem. 52(20), 6362-6368 (2009).