A neutral CB1 antagonist
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ABD459

Item No. 20003

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl](4-methoxyphenyl)-methanone
CAS Number
1047670-51-8
Molecular Formula
C24H17BrCl2N2O2
Formula Weight
516.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/ml
λmax
249, 295 nm
SMILES
O=C(C1=NN(C2=C(Cl)C=C(Cl)C=C2)C(C3=CC=C(Br)C=C3)=C1C)C4=CC=C(OC)C=C4
InChi Code
InChI=1S/C24H17BrCl2N2O2/c1-14-22(24(30)16-5-10-19(31-2)11-6-16)28-29(21-12-9-18(26)13-20(21)27)23(14)15-3-7-17(25)8-4-15/h3-13H,1-2H3
InChi Key
ZUDJJNLJDWKCNV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $295

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    10 mg

    $553

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM).1 It inhibits food consumption in nonfasted mice without affecting motor activity.1 ABD459 reduces active food seeking for 5-6 hours after treatment, with no rebound after washout. ABD459 also diminishes rapid eye movement (REM) sleep, with no alterations of wakefulness or non-REM sleep.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goonawardena, A.V., Plano, A., Robinson, L., et al. Modulation of food consumption and sleep-wake in mice by the neutral CB1 antagonist ABD459. Behav. Pharmacol. 26(3), 289-303 (2015).