Scopoletin (CAS 92-61-5) | Cayman Chemical
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Scopoletin

Item № 20042
CAS № 92-61-5
Purity ≥98%
product image
                (CAS 92-61-5)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     25 mg $38.00 0.00
     50 mg $65.00 0.00
     250 mg $171.00 0.00

Pricing updated 2018-05-26. Prices are subject to change without notice.

Description
Synonyms
  • Esculetin 6-methyl ether
  • NSC 405647

Scopoletin is a natural coumarin found in a variety of plants, including some species from the genus Scopolia. Like esculetin (Item No. 19286), scopoletin binds iron and is used by plants to acquire iron from alkaline soil.1 Scopoletin inhibits aldose reductase activity in galactose-fed rats, upregulates PPARγ expression, and triggers phosphorylation of Nrf2 in animals.2,3,4

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Technical Information
Formal Name
7-hydroxy-6-methoxy-2H-1-benzopyran-2-one
CAS Number
92-61-5
Synonyms
  • Esculetin 6-methyl ether
  • NSC 405647
Molecular Formula
C10H8O4
Formula Weight
192.2
Purity
≥98%
Formulation
A crystalline solid
λmax
229, 254, 298, 346 nm
SMILES
O=C1C=CC2=CC(OC)=C(O)C=C2O1
InChI Code
InChI=1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3
InChI Key
RODXRVNMMDRFIK-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Clemens, S., and weber, M. The essential role of coumarin secretion for Fe acquisition from alkaline soil. Plant Signal.Behav. 11(2), (2016).

2. Chang, W.-C., Wu, S.-C., Xu, K.-D., et al. Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. Molecules 20(2), 2786-2801 (2015).

3. Kim, J., Kim, C.-S., Lee, Y.M., et al. Scopoletin inhibits rat aldose reductase activity and cataractogenesis in galactose-fed rats. Evid.Based Complement.Alternat.Med 2013:787138, (2013).

4. Zhang, W.Y., Lee, J.-J., Kim, Y., et al. Amelioration of insulin resistance by scopoletin in high-glucose-induced, insulin-resistant HepG2 cells. Horm.Metab.Res. 42(13), 930-935 (2010).

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