A coumarin with diverse biological activities
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Active Metabolite(s)
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Isomer(s)
29338Citropten
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Scoparone

Item No. 20046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dimethoxy-2H-1-benzopyran-2-one
CAS Number
120-08-1
Synonyms
  • Aesculetin dimethyl ether
  • 6,7-Dimethoxycoumarin
  • 6,7-Dimethylesculetin
  • Escoparone
Molecular Formula
C11H10O4
Formula Weight
206.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMF:PBS (pH 7.2)(1:3): 0.25 mg/mLDMSO: 14 mg/mLEthanol: 1 mg/mL
λmax
230, 294, 343 nm
SMILES
O=C1C=CC2=CC(OC)=C(OC)C=C2O1
InChi Code
InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3
InChi Key
GUAFOGOEJLSQBT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

    $128

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    50 mg

    $236

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    250 mg

    $544

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    Cayman Chemical
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    Product Description

    Scoparone is a coumarin that has been found in A. capillaris and has diverse biological activities.1,2,3,4,5 It inhibits angiotensin II-induced extracellular matrix (ECM) remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts when used at concentrations ranging from 1 to 10 µM.1 Scoparone suppresses PDGF-BB-induced rat aortic smooth muscle cell (RASMC) migration and wound healing in a scratch assay.2 In vivo, scoparone (3.5 mg/kg) reduces vascular neointima formation in a rat model of carotid artery balloon injury. Scoparone (80 mg/kg) reduces hepatocyte apoptosis, liver fibrosis, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.3 It reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers.4 Scoparone also inhibits passive cutaneous anaphylaxis in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fu, B., Su, Y., Ma, X., et al. Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts. J. Pharmacol. Sci. 137(2), 110-115 (2018).

    2. Jung, S.H., Lee, G.B., Ryu, Y., et al. Inhibitory effects of scoparone from chestnut inner shell on platelet-derived growth factor-BB-induced vascular smooth muscle cell migration and vascular neointima hyperplasia. J. Sci. Food Agric. 99(9), 4397-4406 (2019).

    3. Liu, B., Deng, X., Jiang, Q., et al. Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice. Int. Immunopharmacol. 75, 105797 (2019).

    4. Son, D.J., Lee, G.R., Oh, S., et al. Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents. Nutrients 7(3), 1945-1964 (2015).

    5. Choi, Y.H., and Yan, G.H. Anti-allergic effects of scoparone on mast cell-mediated allergy model. Phytomedicine 16(12), 1089-1094 (2009).