An antagonist of α- and β-adrenoreceptors
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Analytical Standard(s)
26289Labetalol (hydrochloride)
Labeled Version(s)
31609Labetalol-d5 (hydrochloride)
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Labetalol (hydrochloride)

Item No. 20249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-benzamide, monohydrochloride
CAS Number
32780-64-6
Synonyms
  • AH 5158A
  • Normodyne
  • NSC 290312
  • SCH 15719W
  • Trandate
Molecular Formula
C19H24N2O3 • HCl
Formula Weight
364.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: 0.3 mg/ml
λmax
208, 303 nm
SMILES
OC1=CC=C(C(CNC(C)CCC2=CC=CC=C2)O)C=C1C(N)=O.Cl
InChi Code
InChI=1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H
InChi Key
WQVZLXWQESQGIF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    5 g

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    10 g

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    25 g

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    Product Description

    Labetalol is a competitive antagonist of both α- and β-adrenoreceptors that is effective at nanomolar concentrations.1,2 It is reported to control hypertension.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brittain, R.T., and Levy, G.P. A review of the animal pharmacology of labetalol, a combined α- and β-adrenoceptor-blocking drug. Br. J. Clin. Pharmacol. 3(4 suppl 3), 681-684 (1976).

    2. Richards, D.A. Pharmacological effects of labetalol in man. Br. J. Clin. Pharmacol. 3(4 suppl 3), 721-723 (1976).

    3. Owens, W.B. Blood pressure control in acute cerebrovascular disease. J. Clin. Hypertens. (Greenwich) 13(3), 205-211 (2011).

    4. Kernaghan, D., Duncan, A.C., and McKay, G.A. Hypertension in pregnancy: A review of therapeutic options. Obstet. Med. 5(2), 44-49 (2012).