An internal standard for the quantification of labetalol
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Unlabeled Version(s)
20249Labetalol (hydrochloride)
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Labetalol-d5 (hydrochloride)

Item No. 31609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-(phenyl-d5)propyl)amino]ethyl]-benzamide, monohydrochloride
CAS Number
2713514-78-2
Synonyms
  • AH 5158A-d5
  • SCH 15719W-d5
Molecular Formula
C19H19D5N2O3 • HCl
Formula Weight
369.9
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
OC1=CC=C(C(CNC(C)CCC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])O)C=C1C(N)=O.Cl
InChi Code
InChI=1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H/i2D,3D,4D,5D,6D;
InChi Key
WQVZLXWQESQGIF-CERKJNTMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Labetalol-d5 is intended for use as an internal standard for the quantification of labetalol (Item No. 20249) by GC- or LC-MS. Labetalol is an adrenergic receptor (AR) antagonist.1 It inhibits agonist-induced contraction of rabbit aortic strips, decreases in contractile force in isolated guinea pig atria, and vasorelaxation in isolated guinea pig tracheal strips (pA2s = 6.99, 7.68, and 7.54, respectively), tissues that endogenously express high levels of α-, β1-, and β2-ARs, respectively. Labetalol (2.5-25 mg/kg) reduces blood pressure in spontaneously hypertensive rats. It reduces blood pressure in DOC-salt rats, two-kidney Goldblatt rats, and one-kidney dogs. Labetalol (5 mg/kg) reduces infarct size in a dog model of myocardial infarction induced by occlusion of the left anterior descending artery. Topical administration of labetalol (0.25-1% v/v) reduces intraocular pressure in rabbits. Formulations containing labetalol have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baum, T., and Sybertz, E.J. Pharmacology of labetalol in experimental animals. Am. J. Med. 75(4A), 15-23 (1983).