A bile acid and isomer of cholic acid
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Allocholic Acid

Item No. 30415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5α,7α,12α)-3,7,12-trihydroxy-cholan-24-oic acid
CAS Number
2464-18-8
Synonyms
  • ACA
  • AlloCA
  • allo-Cholic Acid
  • 5α-Allocholic Acid
Molecular Formula
C24H40O5
Formula Weight
408.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
InChi Code
InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14-,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
InChi Key
BHQCQFFYRZLCQQ-PGHAKIONSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Allocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).1 It is typically produced in the fetal or larval stages of development but has been found in adult mammals in the context of cancer or during liver regeneration in rats.1,2 Allocholic acid is a precursor to petromyzonol (Item No. 98250), a bile acid of larval sea lamprey that acts as a migratory pheromone.3 The levels of allocholic acid are elevated in the plasma of mdr2-/- mice, a model of bile duct inflammation leading to hepatocellular carcinoma.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mendoza, M.E., Monte, M.J., Serrano, M.A., et al. Physiological characteristics of allo-cholic acid. J. Lipid Res. 44(1), 84-92 (2003).

    2. Monte, M.J., Martinez-Diez, M.C., El-Mir, M.Y., et al. Changes in the pool of bile acids in hepatocyte nuclei during rat liver regeneration. J. Hepatol. 36(4), 534-542 (2002).

    3. Gandre-Babbe, S., and van der Bliek, A.M. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol. Biol. Cell 19(6), 2402-2412 (2008).

    4. Han, J., Liu, Y., Wang, R., et al. Metabolic profiling of bile acids in human and mouse blood by LC-MS/MS in combination with phospholipid-depletion solid-phase extraction. Anal. Chem. 87(2), 1127-1136 (2015).