A mycotoxin and an active metabolite of T-2 toxin
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Labeled Version(s)
31299HT-2 Toxin-13C22
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HT-2 Toxin

Item No. 20431

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12,13-epoxy-trichothec-9-ene-3α,4β,8α,15-tetrol, 15-acetate 8-(3-methylbutanoate)
CAS Number
26934-87-2
Synonyms
  • NSC 278571
Molecular Formula
C22H32O8
Formula Weight
424.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: 5 mg/mlDMSO: SolubleEthanol: Soluble
SMILES
CC1=C[C@]2([H])[C@]([C@]([C@H](O)[C@H]3O)(C)[C@@]4(OC4)[C@]3([H])O2)(COC(C)=O)C[C@@H]1OC(CC(C)C)=O
InChi Code
InChI=1S/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3/t14-,15+,17+,18+,19+,20+,21+,22-/m0/s1
InChi Key
PNKLMTPXERFKEN-MLXHEQMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin (Item No. 11444).1,2 Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2 HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50 values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells (HUVECs) with an IC50 value of 56.4 ng/ml.1 It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.3 HT-2 toxin has been found in cereal grains and food products.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nielsen, C., Casteel, M., Didier, A., et al. Trichothecene-induced cytotoxicity on human cell lines. Mycotoxin Res. 25(2), 77-84 (2009).

    2. Nathanail, A.V., Varga, E., Meng-Reiterer, J., et al. Metabolism of the fusarium mycotoxins T-2 toxin and HT-2 toxin in wheat. J. Agric. Food Chem. 63(35), 7862-7872 (2015).

    3. Zhang, L., Li, L., Xu, J., et al. HT-2 toxin exposure induces mitochondria dysfunction and DNA damage during mouse early embryo development. Reprod. Toxicol. 85, 104-109 (2019).

    4. Langseth, W., and Rundberget, T. The occurrence of HT-2 toxin and other trichothecenes in Norwegian cereals. Mycopathologia 147(3), 157-165 (1999).

    5. Al-Taher, F., Cappozzo, J., Zweigenbaum, J., et al. Detection and quantitation of mycotoxins in infant cereals in the U.S. market by LC-MS/MS using a stable isotope dilution assay. Food Control 72(Part A), 27-35 (2017).