A muscarinic acetylcholine receptor antagonist
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Aclidinium (bromide)

Item No. 20699

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R)-3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, monobromide
CAS Number
320345-99-1
Synonyms
  • LAS 34273
  • LAS-W 330
Molecular Formula
C26H30NO4S2 • Br
Formula Weight
564.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 0.14 mg/ml
λmax
221, 238, 276 nm
SMILES
O=C(C(C1=CC=CS1)(O)C2=CC=CS2)O[C@@H]3C4CC[N+](CC4)(CCCOC5=CC=CC=C5)C3.[Br-]
InChi Code
InChI=1S/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21;/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2;1H/q+1;/p-1/t20?,22-,27?;/m0./s1
InChi Key
XLAKJQPTOJHYDR-QTQXQZBYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $153

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    50 mg

    $268

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    Product Description

    Aclidinium is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.1, 0.14, 0.14, 0.21, and 0.16 for the M1-M5 receptors, respectively).1 It induces relaxation of precontracted isolated human bronchi when used at a concentration of 0.1 µM.2 Aclidinium reduces bronchoconstriction induced by ACh (Item No. 23829) in anesthetized guinea pigs when administered via nebulization.1 Formulations containing aclidinium have been used in the treatment of chronic obstructive pulmonary disease (COPD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gavaldà, A., Miralpeix, M.R., I. , Otal, R., et al. Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile. J. Pharmacol. Exp. Ther. 331(2), 740-751 (2009).

    2. Rogliani, P., Calzetta, L., Ora, J., et al. Pharmacological assessment of the onset of action of aclidinium and glycopyrronium versus tiotropium in COPD patients and human isolated bronchi. Eur. J. Pharmacol. 761, 383-390 (2015).