An RXR antagonist
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HX 531

Item No. 20762

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-benzoic acid
CAS Number
188844-34-0
Molecular Formula
C29H29N3O4
Formula Weight
483.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:6): 0.14 mg/mlDMSO: 10 mg/mlEthanol: 0.12 mg/ml
λmax
264 nm
SMILES
CC1(C)C2=C(C=C(N(C)C(C=CC([N+]([O-])=O)=C3)=C3N=C4C5=CC=C(C(O)=O)C=C5)C4=C2)C(C)(C)CC1
InChi Code
InChI=1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)
InChi Key
SXKPGYKPQPYJER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $378

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid (Item No. 14587)-induced transactivation of RXR.1 It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Konta, T., Xu, Q., Furusu, A., et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. The Journal of Biological Chemisty 276(16), 12697-12701 (2001).

    2. Yamauchi, T., Waki, H., Kamon, J., et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J. Clin. Invest. 108(7), 1001-1013 (2001).