A histone demethylase inhibitor
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AS-8351

Item No. 20811

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide, 4-pyridinecarboxylic acid
CAS Number
796-42-9
Synonyms
  • NCI 51355
  • NSC 51355
Molecular Formula
C17H13N3O2
Formula Weight
291.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/ml
λmax
229, 257, 327, 367 nm
SMILES
O=C(N/N=C/C1=C(O)C=CC2=C1C=CC=C2)C3=CC=NC=C3
InChi Code
InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
InChi Key
WQSHHAVECQJKLX-YBFXNURJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

    $117

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    25 mg

    $244

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    Product Description

    AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021 (Item No. 13122), A 83-01 (Item No. 9001799), BIX01294 (Item No. 13124), SC-1 (Item No. 10009557), Y-27632 (Item No. 10005583), OAC2 (Item No. 14103), SU 16f (Item No. 19555), and JNJ-10198409 (Item No. 10008131) to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cao, N., Huang, Y., Zheng, J., et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352(6290), 1216-1220 (2016).