An active metabolite of the laxatives bisacodyl and sodium picosulfate
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Desacetyl Bisacodyl

Item No. 20928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-(2-pyridinylmethylene)bis-phenol
CAS Number
603-41-8
Synonyms
  • DAB
  • DDPM
Molecular Formula
C18H15NO2
Formula Weight
277.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:8): 0.11 mg/mlEthanol: 2.5 mg/ml
λmax
229, 267 nm
SMILES
OC(C=C1)=CC=C1C(C2=CC=CC=N2)C3=CC=C(O)C=C3
InChi Code
InChI=1S/C18H15NO2/c20-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(21)11-7-14/h1-12,18,20-21H
InChi Key
LJROKJGQSPMTKB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $31

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    10 mg

    $48

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    50 mg

    $116

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    100 mg

    $143

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    Product Description

    Desacetyl bisacodyl (DAB) is an active metabolite of two stimulant laxatives, bisacodyl and sodium picosulfate.1,2 DAB evokes several effects at the colon or rectum, including increased mucus and chloride secretion.3,4 Oral administration of bisacodyl leads to decreased expression of aquaporin-3 in the colon of rats.5 The effects of both DAB and bisacodyl can be blocked with cyclooxygenase (COX) inhibitors, suggesting that products of the COX signaling pathway contribute to laxative effects.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Friedrich, C., Richter, E., Trommeshauser, D., et al. Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women. Drug Metab. Pharmacokinet. 26(5), 458-464 (2011).

    2. Jauch, R., Hankwitz, R., Beschke, K., et al. Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate. Arzneimittelforschung 25(11), 1796-1800 (1975).

    3. Farack, U.M., Gruber, E., and Loeschke, K. The influence of bisacodyl and deacetylbisacodyl on mucus secretion, mucus synthesis and electrolyte movements in the rat colon in vivo. Eur. J. Pharmacol. 117(2), 215-222 (1985).

    4. Fujita, T., Karaki, S.-i., Tateoka, T., et al. Desacetyl bisacodyl-induced epithelial Cl(−) secretion in rat colon and rectum. Biomed. Res. 37(1), 13-20 (2016).

    5. Ikarashi, N., Baba, K., Ushiki, T., et al. The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 301(5), G887-G895 (2011).