A prodrug form of desacetyl bisacodyl
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Active Metabolite(s)
20928Desacetyl Bisacodyl
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Bisacodyl

Item No. 28826

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-(2-pyridinylmethylene)bis-phenol, 1,1′-diacetate
CAS Number
603-50-9
Synonyms
  • NSC 614826
Molecular Formula
C22H19NO4
Formula Weight
361.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:7): 0.12 mg/mlDMSO: 1 mg/ml
SMILES
CC(OC(C=C1)=CC=C1C(C2=CC=CC=N2)C3=CC=C(OC(C)=O)C=C3)=O
InChi Code
InChI=1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3
InChi Key
KHOITXIGCFIULA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $95

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    25 g

    $164

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    50 g

    $279

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    100 g

    $510

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    Product Description

    Bisacodyl is a prodrug form of the stimulant laxative desacetyl bisacodyl (Item No. 20928).1 It reduces the activity of Na+/K+-ATPases in isolated rat colon following administration in the drinking water at a concentration of 83 µM.2 Bisacodyl (20 mg/kg) decreases colonic aquaporin-3 levels and increases stool water content in rats, effects that are reversed by the COX inhibitor indomethacin (Item No. 70270).3 Formulations containing bisacodyl have been used in the treatment of constipation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jauch, R., Hankwitz, R., Beschke, K., et al. Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate. Arzneimittelforschung 25(11), 1796-1800 (1975).

    2. Schreiner, J., Nell, G., and Loeschke, K. Effect of diphenolic laxatives on Na+-K+-activated ATPase and cyclic nucleotide content of rat colon mucosa in vivo. Naunyn-Schmiedebergs Arch. Pharmacol. 313(3), 249-255 (1980).

    3. Ikarashi, N., Baba, K., Ushiki, T., et al. The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 301(5), G887-G895 (2011).