A stimulant laxative and prodrug form of desacetyl bisacodyl
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Active Metabolite(s)
20928Desacetyl Bisacodyl
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Picosulfate (sodium salt hydrate)

Item No. 34566

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-(2-pyridinylmethylene)bis-phenol, 1,1′-bis(hydrogen sulfate), disodium salt, monohydrate
CAS Number
1307301-38-7
Molecular Formula
C18H13NO8S2 • 2Na [H2O]
Formula Weight
499.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=S([O-])(OC1=CC=C(C(C2=CC=C(C=C2)OS(=O)([O-])=O)C3=CC=CC=N3)C=C1)=O.[Na+].[Na+].O
InChi Code
InChI=1S/C18H15NO8S2.2Na.H2O/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;;1H2/q;2*+1;/p-2
InChi Key
FHYUVJHZGPGDSP-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $49

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    100 mg

    $86

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    250 mg

    $190

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    500 mg

    $329

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    Product Description

    Picosulfate is a stimulant laxative and prodrug form of desacetyl bisacodyl (DAB; Item No. 20928).1 Unlike bisacodyl (Item No. 28826), picosulfate is hydrolyzed to DAB by colonic microbiota. Picosulfate (5 mg/kg) increases excreted fecal weight in a rat model of loperamide-induced constipation.2 Formulations containing picosulfate have been used for colonoscopy preparation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Twycross, R., Sykes, N., Mihalyo, M., et al. Stimulant laxatives and opioid-induced constipation. J. Pain Symptom Manage. 43(2), 306-313 (2012).

    2. Méité, S., Bahi, C., Yéo, D., et al. Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats. BMC Complement. Altern. Med. 10, 7 (2010).