An active metabolite of 5-fluorouracil
Related Products
Parent Compound(s)
144165-Fluorouracil
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

5,6-dihydro-5-Fluorouracil

Item No. 20977

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluorodihydro-2,4(1H,3H)-pyrimidinedione
CAS Number
696-06-0
Synonyms
  • 5-DHFU
  • 5-Fluorodihydropyrimidine-2,4-dione
  • 5-Fluorodihydrouracil
  • 5-Fluoro-5,6-dihydrouracil
  • 5-FUH2
Molecular Formula
C4H5FN2O2
Formula Weight
132.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 60 mg/mlDMSO: 53 mg/mlEthanol: 0.8 mg/mlPBS (pH 7.2): 8 mg/ml
λmax
203 nm
SMILES
O=C1NC(NCC1F)=O
InChi Code
InChI=1S/C4H5FN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9)
InChi Key
RAIRJKWTBBDDAR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $98

    Add

    10 mg

    $186

    Add

    25 mg

    $440

    Add

    50 mg

    $831

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    5,6-dihydro-5-Fluorouracil is an active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (Item No. 14416).1 It is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50 = 13.5 µM). Intravenous administration of 5,6-dihydro-5-fluorouracil (90 mg/kg per week), in combination with 5-fluorouracil and the DPD inhibitor eniluracil (Item No. 34251), reduces tumor growth in a rat model of colon carcinoma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fischel, J.-L., Formento, P., Ciccolini, J., et al. Lack of contribution of dihydrofluorouracil and α-fluoro-β-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes. Anticancer Drugs 15(10), 969-974 (2004).

    2. Spector, T., Cao, S., Rustum, Y.M., et al. Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil. Cancer Res. 55(6), 1239-1241 (1995).