A CB1 receptor antagonist
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NIDA-41020

Item No. 21020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide
CAS Number
502486-89-7
Molecular Formula
C23H24Cl2N4O2
Formula Weight
459.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: <100mMEthanol: <100mM
SMILES
ClC1=CC=C(N2C(C3=CC=C(OC)C=C3)=C(C)C(C(NN4CCCCC4)=O)=N2)C(Cl)=C1
InChi Code
InChI=1S/C23H24Cl2N4O2/c1-15-21(23(30)27-28-12-4-3-5-13-28)26-29(20-11-8-17(24)14-19(20)25)22(15)16-6-9-18(31-2)10-7-16/h6-11,14H,3-5,12-13H2,1-2H3,(H,27,30)
InChi Key
KWDBQJRWPWTGPF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $143

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    10 mg

    $241

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    50 mg

    $1,009

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    Product Description

    NIDA-41020 is a cannabinoid (CB) receptor 1 antagonist (Ki = 4.1 nM).1 It binds selectively to CB1 over CB2 (Kbs = 26 and 831 nM, respectively).2 NIDA-41020 was designed as a potential radioligand for use in positron emission tomography (PET).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Katoch-Rouse, R., Pavlova, O.A., Caulder, T., et al. Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: Development of central cannabinoid receptor ligands with lower lipophilicity. J. Med. Chem. 46(4), 642-645 (2003).

    2. Donohue, S.R., Halldin, C., and Pike, V.W. Synthesis and structure-activity relationships (SARs) of 1,5-diarylpyrazole cannabinoid type-1 (CB1) receptor ligands for potential use in molecular imaging. Bioorg. Med. Chem. 14(11), 3712-3720 (2006).