A PEGylated building block
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PEG diamine

Item No. 21174

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(2-aminoethyl)-ω-(2-aminoethoxy)-poly(oxy-1,2-ethanediyl)
CAS Number
24991-53-5
Synonyms
  • PEG-bis-amine
  • Polyoxyethylene-bis-amine
Molecular Formula
(C2H4O)nC4H12N2O
Purity
≥95%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlEthanol: 33 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
NCCOCCOCCN
InChi Code
InChI=1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2
InChi Key
IWBOPFCKHIJFMS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $213

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    5 g

    $744

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    Cayman Chemical
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    Product Description

    PEG diamine is a PEGylated building block.1,2 It has been used as a linker to conjugate folic acid (Item No. 20515) to 1,2-distearoyl-rac-glycero-PE (1,2-DSPE) as a component in the formation of doxorubicin-containing liposomes with anticancer activity.1 PEG diamine has also been conjugated to oleanolic acid (Item No. 11726), which improves oleanolic acid-induced inhibition of cell proliferation by 677-fold in HepG2 hepatocellular carcinoma cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, R.J., and Low, P.S. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim. Biophys. Acta 1233(2), 134-144 (1995).

    2. Jannus, F., Medina-O'Donnell, M., Rivas, F., et al. A diamine-PEGylated oleanolic acid derivative induced efficient apoptosis through a death receptor and mitochondrial apoptotic pathway in HepG2 human hepatoma cells. Biomolecules 10(10), 1375 (2020).