An inactive control for glucagon receptor antagonist I
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Glucagon Receptor Antagonist Inactive Control

Item No. 21188

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-bromo-N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-benzamide
CAS Number
362482-00-6
Synonyms
  • GCGR Antagonist Inactive Control
Molecular Formula
C21H23BrN2OS
Formula Weight
431.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
246, 322 nm
SMILES
CCC(C)(C)C1CCC(C(C#N)=C(NC(C2=CC=C(Br)C=C2)=O)S3)=C3C1
InChi Code
InChI=1S/C21H23BrN2OS/c1-4-21(2,3)14-7-10-16-17(12-23)20(26-18(16)11-14)24-19(25)13-5-8-15(22)9-6-13/h5-6,8-9,14H,4,7,10-11H2,1-3H3,(H,24,25)
InChi Key
GINRSMLGSRKRLT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Glucagon receptor antagonist inactive control is an analog of glucagon receptor antagonist I (Item No. 21223).1 It inhibits glucagon binding to the glucagon receptor (GCGR) by only 20% in CHO cells expressing human GCGR when used at a concentration of 10 µM. Glucagon receptor antagonist inactive control has no effect on glucagon-induced glycogenolysis in primary human hepatocytes when used at concentrations of 10 or 30 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qureshi, S.A., Candelore, M.R., Xie, D., et al. A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes 53(12), 3267-3273 (2004).