A potent, reversible AMPK inhibitor
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Alternative(s)
11967Dorsomorphin
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Dorsomorphin (hydrochloride)

Item No. 21207

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine, dihydrochloride
CAS Number
1219168-18-9
Synonyms
  • BML-275
  • Compound C
  • CpdC
Molecular Formula
C24H25N5O • 2HCl
Formula Weight
472.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 0.50 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
238, 271, 334, 366 nm
SMILES
N1(CCOC2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC=C5)C=N4)C=C2)CCCCC1.Cl.Cl
InChi Code
InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
InChi Key
RJDVIJJQKMGPMV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.1 Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).2 Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, G., Myers, R., Li, Y., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108(8), 1167-1174 (2001).

    2. Yu, P.B., Hong, C.C., Sachidanandan, C., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 4(1), 33-41 (2008).

    3. Vucicevic, L., Misirkic, M., Janjetovic, K., et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 7(1), 40-50 (2011).