A histamine H2 receptor antagonist
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Active Metabolite(s)
36111Roxatidine
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Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Roxatidine Acetate (hydrochloride)

Item No. 21248

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(acetyloxy)-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-acetamide, monohydrochloride
CAS Number
93793-83-0
Synonyms
  • HOE 760
  • TZU-0460
Molecular Formula
C19H28N2O4 • HCl
Formula Weight
384.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 78 mg/mlEthanol: 12 mg/mlWater: 77 mg/ml
λmax
223, 277 nm
SMILES
O=C(COC(C)=O)NCCCOC1=CC=CC(CN2CCCCC2)=C1.Cl
InChi Code
InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
InChi Key
FEWCTJHCXOHWNL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    500 mg

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    1 g

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    5 g

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    Product Description

    Roxatidine acetate is a competitive histamine H2 receptor antagonist that upon oral absorption is rapidly converted to its active metabolite roxatidine.1 By inhibiting the binding of histamine to H2 receptors, roxatidine reduces both intracellular cAMP concentrations and gastric acid secretion by parietal cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murdoch, D., and McTavish, D. Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs 42(2), 240-260 (1991).