A histamine H2 receptor antagonist and major active metabolite of roxatidine acetate
Related Products
Labeled Version(s)
34007Roxatidine-d10 (hemioxalate)
Pro-drug Form(s)
21248Roxatidine Acetate (hydrochloride)
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Roxatidine

Item No. 36111

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-acetamide
CAS Number
78273-80-0
Molecular Formula
C17H26N2O3
Formula Weight
306.4
Purity
≥95%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMSO: up to 25 mg/ml
SMILES
O=C(CO)NCCCOC1=CC=CC(CN2CCCCC2)=C1
InChi Code
InChI=1S/C17H26N2O3/c20-14-17(21)18-8-5-11-22-16-7-4-6-15(12-16)13-19-9-2-1-3-10-19/h4,6-7,12,20H,1-3,5,8-11,13-14H2,(H,18,21)
InChi Key
BCCREUFCSIMJFS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $44

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    1 mg

    $71

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    5 mg

    $304

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    10 mg

    $520

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    Product Description

    Roxatidine is a histamine H2 receptor antagonist and major active metabolite of roxatidine acetate (Item No. 21248).1 Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50 = 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2 = 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin (Item No. 70270).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sewing, K.-F., Beil, W., and Hannemann, H. Comparative pharmacology of histamine H2-receptor antagonists. Drugs 35(Suppl. 3), 25-29 (1988).

    2. Umegaki, E., Yoda, Y., Tokioka, S., et al. Protective effect of roxatidine against indomethacin induced small intestinal mucosal injury in rats. J. Gastroenterol. Hepatol. 25(Suppl. 1), S35-S40 (2010).