An antagonist of muscarinic receptors
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Labeled Version(s)
26686Trospium-d8 (chloride)
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Trospium (chloride)

Item No. 21279

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,3β,5α)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], monochloride
CAS Number
10405-02-4
Synonyms
  • Relaspium
Molecular Formula
C25H30NO3 • Cl
Formula Weight
428.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.16 mg/mlEthanol: 0.2 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)OC3C[C@]([N+]45CCCC4)([H])CC[C@@]5([H])C3.[Cl-]
InChi Code
InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22-;/m0./s1
InChi Key
RVCSYOQWLPPAOA-VROPFNGYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

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    500 mg

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    Product Description

    Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).1 Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hegde, S.S. Muscarinic receptors in the bladder: From basic research to therapeutics. Br. J. Pharmacol. 147(2), S80-S87 (2006).

    2. Maggiore, U.L.R., Salvatore, S., Alessandri, F., et al. Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females. Expert Opin. Drug Metab. Toxicol. 8(11), 1387-1408 (2012).

    3. Michel, M.C., and de la Rosette, J.J.M.C.H. Role of muscarinic receptor antagonists in urgency and nocturia. BJU Int. 96(Suppl 1), 37-42 (2005).