An internal standard for the quantification of trospium
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Unlabeled Version(s)
21279Trospium (chloride)
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Trospium-d8 (chloride)

Item No. 26686

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,3s,5S)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ium-2',2',3',3',4',4',5',5'-d8, monochloride
Synonyms
  • Relaspium-d8
Molecular Formula
C25H22D8NO3 • Cl
Formula Weight
436.0
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)OC3C[C@]([N+]45C([2H])([2H])C([2H])([2H])C([2H])([2H])C4([2H])[2H])([H])CC[C@@]5([H])C3.[Cl-]
InChi Code
InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22-;/m0./s1/i7D2,8D2,15D2,16D2;
InChi Key
RVCSYOQWLPPAOA-ZYIGQORTSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $202

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    1 mg

    $380

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    Product Description

    Trospium-d8 is intended for use as an internal standard for the quantification of trospium (Item No. 21279) by GC- or LC-MS. Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively).1 Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hegde, S.S. Muscarinic receptors in the bladder: From basic research to therapeutics. Br. J. Pharmacol. 147(2), S80-S87 (2006).

    2. Maggiore, U.L.R., Salvatore, S., Alessandri, F., et al. Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females. Expert Opin. Drug Metab. Toxicol. 8(11), 1387-1408 (2012).

    3. Michel, M.C., and de la Rosette, J.J.M.C.H. Role of muscarinic receptor antagonists in urgency and nocturia. BJU Int. 96(Suppl 1), 37-42 (2005).