A prodrug form of glucocorticoid mometasone
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Labeled Version(s)
33470Mometasone Furoate-d3
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Mometasone Furoate

Item No. 21365

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,21-dichloro-17-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
CAS Number
83919-23-7
Synonyms
  • SCH 32088
Molecular Formula
C27H30Cl2O6
Formula Weight
521.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mlEthanol: 1.67 mg/ml
λmax
248 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(Cl)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(OC(C5=CC=CO5)=O)C(CCl)=O)=C1
InChi Code
InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
InChi Key
WOFMFGQZHJDGCX-ZULDAHANSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Product Description

    Mometasone furoate is a prodrug form of the synthetic glucocorticoid mometasone (Item No. 31702).1 Intranasal administration of mometasone furoate (1 µg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis.2 Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 µg/ml).3 Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, R., Elf, S., Shan, C., et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat. Cell Biol. 17(11), 1484-1496 (2015).

    2. Altuntaş, E.E., Doğan, O.T., Saraç, B., et al. The effects of mometasone furoate and strontium chloride in a rat model of allergic rhinitis. Ear Nose Throat J. 97(1-2), E1-E7 (2018).

    3. Ogawa, M. Dissociation of local anti-inflammatory effect and systemic effects of mometasone furoate in mice. Immunopharmacol. Immunotoxicol. 31(4), 601-606 (2009).