An internal standard for the quantification of mometasone furoate
Related Products
Unlabeled Version(s)
21365Mometasone Furoate
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Mometasone Furoate-d3

Item No. 33470

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,21-dichloro-17-[(2-furanyl-3,4,5-d3-carbonyl)oxy]-11β-hydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
Molecular Formula
C27H27Cl2D3O6
Formula Weight
524.5
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): soluble
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(Cl)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(OC(C5=C([2H])C([2H])=C([2H])O5)=O)C(CCl)=O)=C1
InChi Code
InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1/i4D,5D,10D
InChi Key
WOFMFGQZHJDGCX-VNOPSDMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $109

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    1 mg

    $196

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    5 mg

    $818

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    Product Description

    Mometasone furoate-d3 is intended for use as an internal standard for the quantification of mometasone furoate (Item No. 21365) by GC- or LC-MS. Mometasone furoate is a prodrug form of the synthetic glucocorticoid mometasone (Item No. 31702).1 Intranasal administration of mometasone furoate (1 µg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis.2 Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 µg/ml).3 Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, C.L., and Kreutner, W. In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneimittelforschung 48(9), 956-960 (1998).

    2. Altuntaş, E.E., Doğan, O.T., Saraç, B., et al. The effects of mometasone furoate and strontium chloride in a rat model of allergic rhinitis. Ear Nose Throat J. 97(1-2), E1-E7 (2018).

    3. Ogawa, M. Dissociation of local anti-inflammatory effect and systemic effects of mometasone furoate in mice. Immunopharmacol. Immunotoxicol. 31(4), 601-606 (2009).