Pricing updated 2019-02-20. Prices are subject to change without notice.
1-Deoxynojirimycin (1-dNM), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. It prevents the formation of complex N-linked oligosaccharides in yeast and intact mammalian cells by inhibiting both α-glucosidase I and II with IC50 values of ~2 µM.1,2 1-dNM, at a concentration of 0.4 mM, is reported to inhibit virus spread in HIV-infected lymphocyte cultures by interfering with α-glucosidase activity.3,4
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Suanier, B., Kilker, R.D., Jr., Tkacz, J.S., et al. Inhibition of N-
Suh, K., Gabel, C.A., and Bergmann, J.E. Identification of a novel mechanism for the removal of glucose residues from high mannose-
Montefiori, D.C., Robinson, W.E., Jr., and Mitchell, W.M. Role of protein N-
Papandréou, M.J., Barbouche, R., Guieu, R., et al. The α-