An inactive analog of CID755673
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kb-NB77-78

Item No. 21562

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-b]pyridin-5-one
CAS Number
1350622-33-1
Molecular Formula
C18H25NO3Si
Formula Weight
331.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 20 mg/ml
λmax
214, 252, 346 nm
SMILES
O=C(OC1=C2C=C(O[Si](C)(C)C(C)(C)C)C=C1)C3=C2CCCN3
InChi Code
InChI=1S/C18H25NO3Si/c1-18(2,3)23(4,5)22-12-8-9-15-14(11-12)13-7-6-10-19-16(13)17(20)21-15/h8-9,11,19H,6-7,10H2,1-5H3
InChi Key
UNMWMPXUIXEQJZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    kb-NB77-78 is an inactive analog of the protein kinase D (PKD) inhibitor CID755673 (Item No. 15924).1 It does not bind PKD1 in a fluorescence polarization assay and has no effect on PKD1 phosphorylation in LNCaP cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. George, K.M., Frantz, M.C., Bravo-Altamirano, K., et al. Design, synthesis, and biological evaluation of PKD inhibitors. Pharmaceutics 3(2), 186-228 (2011).