A potent inhibitor of CCK-inactivating peptidase/TPP-2
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Butabindide (oxalate)

Item No. 21610

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[S-(R*,R*)]-1-(2-amino-1-oxobutyl)-N-butyl-2,3-dihydro-1H-indole-2-carboxamide, monoethanedioate
CAS Number
185213-03-0
Molecular Formula
C17H25N3O2 • C2H2O4
Formula Weight
393.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1.6 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/ml
λmax
250, 280, 288 nm
SMILES
O=C(NCCCC)[C@H]1N(C([C@@H](N)CC)=O)C2=CC=CC=C2C1.OC(C(O)=O)=O
InChi Code
InChI=1S/C17H25N3O2.C2H2O4/c1-3-5-10-19-16(21)15-11-12-8-6-7-9-14(12)20(15)17(22)13(18)4-2;3-1(4)2(5)6/h6-9,13,15H,3-5,10-11,18H2,1-2H3,(H,19,21);(H,3,4)(H,5,6)/t13-,15-;/m0./s1
InChi Key
KKMJFDVOXSGHBF-SLHAJLBXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $132

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    10 mg

    $227

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    25 mg

    $525

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    50 mg

    $918

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    Product Description

    Butabindide is a potent inhibitor of cholecystokinin-inactivating peptidase/tripeptidyl peptidase 2 (CCK-inactivating peptidase/TPP-2; Ki = 7 nM).1 It is selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Kis = >1 μM) as well as CCK receptors (Kis = >0.1 mM). Butabindide (0.1-100 μM) increases levels of CCK octapeptide (Item Nos. 24404 | 23371) in depolarized rat cerebral cortex slices. In vivo, butabindide inhibits CCK-inactivating peptidase/TPP-2 in mouse liver and brain (ID50s = 1.1 and 6.8 mg/kg, respectively). It also enhances CCK octapeptide-induced delay in gastric emptying and reduces food intake in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rose, C., Vargas, F., Facchinetti, P., et al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380(6573), 403-409 (1996).